Buy Melanotan 2: Synthetic Alpha-MSH Analogue Melanogenesis Studies

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Reviewed by Dr. Elena Rostova

Molecular Pharmacology & Analytical Chemistry Reviewer

Expert in peptide receptor kinetics, cellular signaling pathways, and peptide stability.

⚠️ Laboratory Research Notice

All peptide compounds discussed in this guide are strictly intended for in vitro cellular research, analytical laboratory testing, and chemical evaluation. They are not approved for human or animal consumption, diagnostic use, or therapeutic applications.

Melanotan 2 (MT-2) is a synthetic cyclic lactam heptapeptide analogue of alpha-melanocyte-stimulating hormone (alpha-MSH). Engineered originally at the University of Arizona to protect against ultraviolet (UV) radiation-induced skin damage, Melanotan 2 functions as a potent, non-selective agonist across multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R, MC5R).

When researchers buy Melanotan 2, its non-selective receptor profile makes it a versatile tool for studying melanogenesis, eumelanin synthesis, appetite regulation, and central autonomic signaling in cellular and animal models.

Melanogenesis Mechanism: MC1R Activation and Eumelanin Synthesis

In dermal melanocytes, Melanotan 2 binds with high affinity to the melanocortin-1 receptor (MC1R):
– Tyrosinase Upregulation: Gs-protein coupling elevates intracellular cAMP, activating microphthalmia-associated transcription factor (MITF), which transcriptionally upregulates the rate-limiting enzyme tyrosinase.
– Eumelanin Over Pheomelanin: Tyrosinase catalyzes the conversion of tyrosine into dark, photoprotective eumelanin rather than yellowish, pro-oxidant pheomelanin.
– Off-Target Central Receptors: Because MT-2 also binds central MC3R and MC4R, experimental subjects frequently display suppressed appetite and spontaneous sexual arousal behaviors.

🧭 Neuropeptide Pathway: Buy Melanotan 2

Step 1

Dermal MC1R Binding

Melanotan 2 binds melanocortin-1 receptors on skin melanocytes.

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Step 2

cAMP & MITF Cascade

Elevates cAMP and phosphorylates MITF transcription factor.

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Step 3

Tyrosinase Transcription

Activates tyrosinase, driving the synthesis of dense eumelanin pigment.

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Step 4

Photoprotective Shield

Eumelanin caps cellular nuclei, absorbing UV radiation and minimizing DNA breaks.

Chemical Profile of Melanotan 2

Analytical specifications:

📊 Analytical Profile: Buy Melanotan 2

Parameter	Analytical Value
Amino Acid Sequence	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 (amidated C-terminus)
Molecular Formula	C50H69N15O9
Molecular Weight	1024.2 g/mol
Receptor Affinity	MC1R, MC3R, MC4R, MC5R (Non-selective)
Recommended Purity	≥ 99.0% by RP-HPLC

Storage and Reconstitution Protocols

Store dry lyophilized vials at -20°C. Reconstitute with sterile bacteriostatic water. The cyclic lactam structure provides good stability; store working solutions at 2°C to 8°C.

Frequently Asked Questions

❓ How does Melanotan 2 differ from Melanotan 1?

Melanotan 1 is a linear 13-amino-acid peptide specific to MC1R; Melanotan 2 is a cyclic heptapeptide with non-selective activity across MC1R, MC3R, and MC4R.