Buy MOTS-c: Mitochondrial-Derived Peptide in Metabolic Homeostasis

DER

Reviewed by Dr. Elena Rostova

Molecular Pharmacology & Analytical Chemistry Reviewer

Expert in peptide receptor kinetics, cellular signaling pathways, and peptide stability.

⚠️ Laboratory Research Notice

All peptide compounds discussed in this guide are strictly intended for in vitro cellular research, analytical laboratory testing, and chemical evaluation. They are not approved for human or animal consumption, diagnostic use, or therapeutic applications.

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is an extraordinary 16-amino-acid mitochondrial-derived peptide (MDP) encoded entirely within the mitochondrial 12S ribosomal RNA genome. As an endocrine signaling molecule, MOTS-c acts as a cellular ‘exercise mimetic,’ translocating into the cell nucleus during metabolic stress to orchestrate glucose utilization, fatty acid oxidation, and metabolic resilience.

When research teams buy MOTS-c for cellular bioenergetics research, acquiring high-purity lyophilized material is vital to exploring its unique AMPK activation pathways.

Mechanism: The Folate-AICAR-AMPK Metabolic Axis

MOTS-c exerts its metabolic effects through a distinct biochemical cascade:
– Inhibition of the Folate Cycle: MOTS-c inhibits the folate-methionine cycle, which leads to the accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
– AMPK Activation: Accumulated AICAR directly activates AMP-activated protein kinase (AMPK), the cell’s master energy sensor.
– Nuclear Translocation: During metabolic stress, MOTS-c translocates to the nucleus, binding chromatin and coordinating the transcription of nuclear genes that regulate mitochondrial biogenesis and insulin sensitivity.

🧭 Longevity Pathway: Buy Mots-C

Step 1

Mitochondrial Encoding

16-amino-acid peptide encoded within mitochondrial 12S rRNA.

↓

Step 2

Folate Cycle Modulation

Transiently inhibits de novo purine synthesis, elevating intracellular AICAR.

↓

Step 3

AMPK Phosphorylation

Activates AMPK, stimulating GLUT4 glucose uptake in skeletal muscle models.

↓

Step 4

Nuclear Epigenetic Tuning

Translocates into the nucleus to optimize metabolic stress adaptation.

Chemical Profile of MOTS-c

Analytical specifications:

📊 Analytical Specifications: Buy Mots-C

Analytical Metric	Specification
Amino Acid Sequence	Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula	C101H152N28O22S2
Molecular Weight	2174.6 g/mol
Target Enzyme Pathway	AMPK / AICAR / GLUT4 Translocation
Recommended Purity	≥ 98.5% by RP-HPLC

Storage and Reconstitution Protocols

Lyophilized MOTS-c is sensitive to moisture and light. Store at -20°C in an airtight container. Reconstitute with sterile bacteriostatic water and use within 21 to 28 days when refrigerated at 2°C to 8°C.

Frequently Asked Questions

❓ Why is MOTS-c called an exercise mimetic?

Because it activates AMPK and promotes muscle glucose uptake via pathways highly similar to physical endurance training.