Buy SS-31 (Elamipretide): Cardiolipin Protection and Mitochondrial ATP

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Reviewed by Dr. Elena Rostova

Molecular Pharmacology & Analytical Chemistry Reviewer

Expert in peptide receptor kinetics, cellular signaling pathways, and peptide stability.

⚠️ Laboratory Research Notice

All peptide compounds discussed in this guide are strictly intended for in vitro cellular research, analytical laboratory testing, and chemical evaluation. They are not approved for human or animal consumption, diagnostic use, or therapeutic applications.

SS-31, also known as Elamipretide or Bendavia, is a synthetic tetrapeptide with the unique sequence D-Arg-Dmt-Lys-Phe-NH2. Designed with an alternating aromatic-cationic motif, SS-31 readily crosses cell membranes and selectively concentrates more than 1,000-fold in the inner mitochondrial membrane (IMM).

When researchers buy SS-31 peptide, its primary scientific value is its ability to bind selectively to cardiolipin, a unique phospholipid essential for mitochondrial cristae architecture, electron transport chain efficiency, and cellular ATP generation.

Cardiolipin Protection: The Unique Molecular Target of SS-31

Cardiolipin is exclusively located in the inner mitochondrial membrane, where it anchors the electron transport chain complexes (I, III, IV) and ATP synthase into functional supercomplexes. In aging or ischemic cells, cardiolipin readily oxidizes, leading to mitochondrial fragmentation, electron leakage, and reactive oxygen species (ROS) overproduction.

SS-31 specifically binds to cardiolipin via electrostatic and hydrophobic interactions:
– Prevents cardiolipin oxidation and maintains inner membrane curvature.
– Restores electron flux across the electron transport chain, boosting ATP synthesis.
– Inhibits cytochrome c release, protecting cells against apoptotic cell death.

🧭 Longevity Pathway: Buy Ss-31 Peptide

Step 1

Mitochondrial Targeting

Alternating aromatic-cationic motif drives selective uptake into inner mitochondrial membrane.

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Step 2

Cardiolipin Binding

Electrostatic interaction anchors SS-31 directly to cardiolipin phospholipids.

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Step 3

Cristae Stabilization

Preserves cristae architecture and electron transport supercomplexes.

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Step 4

ATP Optimization

Restores mitochondrial ATP production while dramatically suppressing ROS leakage.

Chemical Profile of SS-31 (Elamipretide)

Analytical specifications:

📊 Analytical Specifications: Buy Ss-31 Peptide

Parameter	Analytical Value
Sequence	D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2′,6′-dimethyltyrosine)
Molecular Formula	C32H49N9O5
Molecular Weight	639.8 g/mol
Target Organelle	Inner Mitochondrial Membrane (Cardiolipin)
Recommended Purity	≥ 99.0% by RP-HPLC

Storage and Reconstitution Protocols

Store dry lyophilized SS-31 vials at -20°C. Reconstitute with sterile bacteriostatic water. The peptide dissolves readily into a clear solution. Store reconstituted aliquots at 2°C to 8°C.

Frequently Asked Questions

❓ What is Dmt in the SS-31 sequence?

Dmt stands for 2′,6′-dimethyltyrosine, an unnatural amino acid that scavenges reactive oxygen species directly at the mitochondrial inner membrane.